Mei's Boil Release acidic mist, a fusion of Fire and Water, rapidly corrodes anything, by passing Sukuna's healing. It could melt his defenses and body faster than he can recover.
Pakura's Scorch Release combines Fire and Wind to instantly evaporate all liquid from a target. This terrifying ability bypasses Sukuna's defenses by flash-boiling his cellular moisture.
The Mangekyo Sharingan tracks Sukuna's movements and can trap him in powerful genjutsu like Tsukuyomi. This distorts his reality, attacking all five senses and leaving his body defenseless.
Hashirama's Wood Release, fusing Earth and Water, creates massive wooden constructs that absorb chakra. His True Several Thousand Hands could easily imprison Sukuna, dwarfing even Malevolent Shrine's range.
The Rinnegan, the ultimate ocular Kekkei Genkai, commands gravity and manipulates souls. Its Deva Path can repel Sukuna's attacks with Shinra Tensei or imprison him in a gravitational core via Chibaku Tensei.