The Copy Ninja, Kakashi, mastered all five basic chakra natures, a feat confirmed by databooks. His Sharingan allowed him to copy over a thousand jutsu, showcasing his immense versatility.
Driven by a quest for knowledge, Orochimaru's extensive research and experimentation led him to master all five basic chakra natures, making him a formidable and intelligent shinobi.
The Third Hokage, Hiruzen Sarutobi, earned his "Professor" nickname by mastering all five basic chakra natures. His vast ninjutsu knowledge made him one of the greatest shinobi of his era.
Nagato's Rinnegan granted him mastery over all five basic chakra natures. His incredible power, noted by Jiraiya, allowed him to devastatingly reshape the battlefield.
Already powerful with Kamui and Sharingan, Obito's transformation into the Ten-Tails' jinchuriki during the Fourth Great Ninja War granted him mastery over all five basic chakra natures and Yin-Yang Release.
While famed for his Water Release, the Second Hokage, Tobirama Senju, was also a master of all five basic chakra natures, as confirmed by official databooks.
Madara Uchiha's power was legendary even before the Ten-Tails. Databooks confirm his mastery of all five basic chakra natures, evident in his overwhelming Fire Release attacks.
Though celebrated for his unique Wood Release, Hashirama Senju's mastery extended to all five basic chakra natures, a fact often overlooked due to his signature Kekkei Genkai.
Sasuke Uchiha primarily used Fire and Lightning Release until receiving Six Paths chakra from Hagoromo. This power-up granted him access to all five basic chakra natures.
Naruto Uzumaki achieved his peak power with Six Paths Sage Mode and Hagoromo's chakra. This transformation gave him access to all five basic chakra natures and Yin-Yang Release.