Who Is Strong Adult Sasuke vs. Hashirama?

In a battle between Adult Sasuke and Hashirama Senju, the overwhelming consensus is that Sasuke wins, primarily because his "Six Paths" power scales him into a tier that transcends traditional shinobi limits. 

While Hashirama is the legendary "God of Shinobi," Adult Sasuke's experience fighting Otsutsuki-level threats—beings that far outclass anything from Hashirama's era—places him in a different league entirely. 

The Combat Breakdown

• Speed and Blitzing: A major factor in this fight is speed. Adult Sasuke's movement and reaction speeds are high enough to keep pace with Fused Momoshiki and Isshiki Otsutsuki. Most analysts agree Sasuke could "blitz" (attack before a reaction is possible) Hashirama, potentially ending the fight before the First Hokage can even finish a single hand seal.
• The Rinnegan Factor: Sasuke’s Amenotejikara (teleportation/switching) is a "hax" ability that Hashirama has no counter for. Sasuke can instantly switch places with Hashirama's own wood constructs or weapons, turning the First Hokage's attacks against him.
• Destructive Power vs. Constructs: Hashirama’s most powerful technique, the True Several Thousand Hands statue, is massive, but Sasuke's Perfect Susanoo can fly and maneuver with agility that the statue lacks. Furthermore, Sasuke has been shown easily destroying meteors larger than mountains—feats that suggest he could dismantle Hashirama's wood constructs with Susanoo-infused Chidori or blades.
• Genjutsu: Sasuke possesses some of the strongest genjutsu in the series, capable of trapping all nine Tailed Beasts simultaneously with a single glance. Since Hashirama often fights with his eyes open and lacks specialized Rinnegan-level genjutsu resistance, he is highly vulnerable to an instant mental takedown. 

Hashirama's Win Conditions (The "Long Shot")

For Hashirama to stand a chance, he would need to rely on the sheer scale of his Wood Style: 

• Chakra Absorption: His Wood Dragon can drain chakra on contact, which could be dangerous if Sasuke is already low on reserves.
• Regeneration: Hashirama's passive healing is so advanced it doesn't require hand signs, potentially allowing him to survive many of Sasuke’s standard strikes.
• Pollens & Poisons: Techniques like Advent of a World of Flowering Trees release pollens that can incapacitate anyone who breathes them in, though Sasuke's Susanoo could likely act as a barrier. 

Summary of Key Stats

Conclusion

Hashirama is the peak of what a "regular" human shinobi can achieve through training and lineage. Sasuke, however, possesses the Six Paths Chakra of Indra and a Rinnegan given by the Sage of Six Paths himself. This "Godly" enhancement bridges a gap that no amount of Wood Style or Sage Mode can close. Sasuke likely wins with "low difficulty".